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January 1, 2003Pacing and Clinical Electrophysiology

High Defibrillation Thresholds in Transvenous Biphasic Implantable Defibrillators:

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Why the study?

Do high defibrillation thresholds (≥ 18 J) predict mortality at 6 months in patients receiving transvenous biphasic implantable defibrillators?

Population

968 patients from two separate clinical studies who received a Medtronic cardioverter defibrillator from…

Comparison

High defibrillation thresholds (≥ 18 J) vs Low defibrillation thresholds (< 18 J)

Design

Cohort

Follow-up

6 months

Authors

HSHimanshu H. ShuklaCollege of Central FloridaGFGreg C. FlakerUniversity of North Carolina at Chapel HillVJVinod JayamFord Motor Company (United States)

Discussion

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Overview

High defibrillation thresholds should not prompt practice changes; leaves open their independent prognostic value in contemporary cohorts.

Structured PICO

Do high defibrillation thresholds (≥ 18 J) predict mortality at 6 months in patients receiving transvenous biphasic implantable defibrillators?

P
Population
968 patients from two separate clinical studies who received a Medtronic cardioverter defibrillator from January 1995 through November 1999 and who had DFT testing measured by a binary search protocol.
I
Intervention
High defibrillation thresholds (≥ 18 J)
C
Comparator
Low defibrillation thresholds (< 18 J)
O
Outcome
Mortality at 6 monthshard clinical

High defibrillation thresholds (≥ 18 J) are associated with worse baseline clinical status but do not independently predict increased mortality at 6 months.

Cite This Study

Shukla et al. (2003) studied this question.

synapsesocial.com/papers/6a70f1ba35aa2c282ce245behttps://doi.org/10.1046/j.1460-9592.2003.00148.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is Defibrillation Testing Safe?1991 · 50 citations
  2. 2Long-term outcome with the automatic implantable cardioverter-defibrillator1989 · 721 citations
  3. 3The Effect of Chronic Oral and Acute Intravenous Amiodarone Administration on Ventricular Defibrillation Threshold Using Implanted Electrodes in Dogs1989 · 56 citations
  4. 4A simplified, single-lead unipolar transvenous cardioversion-defibrillation system.1993 · 210 citations
  5. 5Clinical characteristics and outcome of patients with high defibrillation thresholds. A multicenter study.1992 · 174 citations