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November 24, 2021Frontiers in Cardiovascular MedicineOpen Access

MicroRNAs as Biomarkers and Therapeutic Targets in Doxorubicin-Induced Cardiomyopathy: A Review

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Why the study?

Doxorubicin clinical utility is limited by fatal cardiotoxicity and difficult early diagnosis, necessitating understanding of underlying mechanisms to develop early intervention strategies before irreversible myocardial damage occurs.

Design

Review

Authors

LCLiuying ChenWestlake UniversityYXYizhou XuWestlake University

Discussion

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Implication

Urges mechanism-based early intervention strategies in DIC; leaves open specific therapeutic targets for prospective validation.

Structured PICO

P
Population
Patients or models with doxorubicin-induced cardiomyopathy (DIC)
I
Intervention
MicroRNAs (as diagnostic biomarkers and therapeutic targets)

MicroRNAs show promise as diagnostic biomarkers and therapeutic targets for early intervention in doxorubicin-induced cardiomyopathy.

Cite This Study

Chen et al. (2021) studied this question.

synapsesocial.com/papers/6a70f1bae5469ee92be19b17https://doi.org/10.3389/fcvm.2021.740515
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity2008 · 180 citations
  2. 2Cardioprotection and Safety of Dexrazoxane in Patients Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Advanced-Stage Lymphoblastic Non-Hodgkin Lymphoma: A Report of the Children’s Oncology Group Randomized Trial Pediatric Oncology Group 94042015 · 205 citations
  3. 3The Effects of Inhibition of MicroRNA-375 in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity2020 · 18 citations
  4. 4Dexrazoxane Protects Cardiomyocyte from Doxorubicin‐Induced Apoptosis by Modulating miR‐17‐5p2020 · 55 citations
  5. 5Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway2010 · 210 citations