Key result
Non-coding RNAs regulate doxorubicin-induced cardiotoxicity by modulating cell death and oxidative stress.
Why the study?
Severe cardiotoxicity restricts the long-term use of doxorubicin in cancer treatment, prompting interest in non-coding RNAs as potential regulators of this adverse effect.
Understanding the roles of non-coding RNAs in doxorubicin-induced cardiotoxicity could pave the way for developing novel cardioprotective strategies.
May support preclinical testing of non-coding RNAs to mitigate doxorubicin cardiotoxicity; leaves open clinical translation and safety.
Doxorubicin, a commonly prescribed chemotherapeutic drug in clinical practice, is associated with severe cardiotoxicity that restricts its long-term use in cancer treatment. Recent studies have highlighted the critical roles of non-coding RNAs (ncRNAs) in the regulation of doxorubicin-induced cardiotoxicity (DIC). Notably, ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, display critical functions in various DIC-associated cellular processes, such as cell death, oxidative stress, and mitochondrial dysfunction, all of which contribute to the pathophysiology of DIC. Accumulated evidence indicates that ncRNAs regulate gene expression by interacting with DNAs, RNAs, proteins, and lipids, presenting a potential avenue to alleviate the adverse effects of doxorubicin on hearts. This review discusses the emerging research progress focusing on the molecular mechanisms by which ncRNAs regulate DIC. Understanding the complicated and essential roles of ncRNAs in DIC could thus pave the way for developing novel cardioprotective strategies.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2025) conducted a review in Doxorubicin-induced cardiotoxicity. Non-coding RNAs was evaluated. Non-coding RNAs regulate doxorubicin-induced cardiotoxicity by modulating cellular processes like cell death and oxidative stress, presenting a potential avenue for cardioprotective strategies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: