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July 23, 2004Physiological Measurement

A physiologically representativein vitromodel of the coronary circulation

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Population

In vitro model of the coronary circulation

Design

Preclinical

Authors

MGMaartje GevenEindhoven University of TechnologyVBVincent N BohtéEindhoven University of TechnologyWAWilbert AarnoudseRadboud University Nijmegen

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Overview

Enables preclinical testing of coronary diagnostics; leaves open clinical translation pending validation.

Structured PICO

P
Population
In vitro model of the coronary circulation
I
Intervention
Development of a lumped parameter mathematical model with a collapsible tube representing the endocardial part of the myocardium
O
Outcome
Similarity of pressure and flow signals to physiological human coronary pressure and flow under baseline and hyperaemic conditionssurrogate

A newly developed in vitro model successfully mimics human coronary pressure and flow, providing a platform for evaluating clinical diagnostic techniques.

Cite This Study

Geven et al. (2004) studied this question.

synapsesocial.com/papers/6a70f1df35aa2c282ce24611https://doi.org/10.1088/0967-3334/25/4/009
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  1. 1Interaction Between Intramyocardial Pressure (IMP) and Myocardial Circulation1985 · 82 citations
  2. 2Inhibition of coronary blood flow by a vascular waterfall mechanism.1975 · 345 citations
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  4. 4Assessing coronary artery stenosis severity: In vitro validation of the concept of fractional flow reserve1999 · 16 citations
  5. 5Contractility is the main determinant of coronary systolic flow impediment1989 · 112 citations