Why the study?
Does intracoronary streptokinase infusion cause systemic fibrinolytic activity in patients with acute myocardial infarction and coronary insufficiency?
Population
25 patients with acute myocardial infarction (n=23) or coronary insufficiency (n=2)
Design
Case_series
Follow-up
Up to 48 hours
Authors
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May warrant coagulation monitoring with intracoronary streptokinase; Level 5 data leaves open confirmation in randomized trials.
Does intracoronary streptokinase infusion cause systemic fibrinolytic activity in patients with acute myocardial infarction and coronary insufficiency?
Intracoronary administration of 'low-dose' streptokinase for acute myocardial infarction frequently results in significant systemic fibrinolytic activity and altered coagulation variables for 24-48 hours.
Cowley et al. (1983) studied this question.
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