Why the study?
Does longterm treatment containing propranolol reduce the incidence of first myocardial infarction in severe uncomplicated essential hypertensive patients compared to hypotensive agents excluding beta-receptor blockade?
Does longterm treatment containing propranolol reduce the incidence of first myocardial infarction in severe uncomplicated essential hypertensive patients compared to hypotensive agents excluding beta-receptor blockade?
Longterm treatment with propranolol significantly reduced the incidence of first myocardial infarction in patients with severe uncomplicated essential hypertension compared to non-beta-blocker hypotensive agents.
Propranolol was associated with fewer first MIs in severe hypertension; leaves open whether beta-blockade confers protection beyond other agents.
After some exclusions, 169 severe uncomplicated essential hypertensive patients presenting consecutively were divided into two groups according to their treatment. Of these, 121 had been given longterm treatment containing propranolol (PC group) and forty-eight had been treated with hypotensive agents excluding any beta-receptor-blocker group, the non-beta-receptor-blocker (NBB) group. 2. There were no significant differences in myocardial infarction risk factors between the two groups. 3. After a mean follow-up of 5-25 years, nine of the 121 subjects (7-5%) in the PC group had suffered first infarctions and fifteen of the forty-eight subjects (31%) in the NBB group, a significant difference (P less than 0-01). 4. It was concluded that the presence of propranolol had prevented more or caused fewer infarctions, perhaps a combination of both, than had the older hypotensive agents unsupported by beta-receptor blockade.
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I M Stewart (1976) studied this question.
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