What does this research mean for the field?

Long-term administration of propranolol reduces coronary incidence, including recurrent nonfatal reinfarction and fatal coronary heart disease, by 23% in patients who have had a recent myocardial infarction. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To evaluate the effectiveness of long-term propranolol administration in reducing recurrent myocardial infarction and coronary heart disease mortality.

November 25, 1983JAMA

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

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Why the study?

Does long-term administration of propranolol reduce coronary incidence in patients with a confirmed myocardial infarction?

Population

3,837 patients who had at least one confirmed myocardial infarction

Comparison

Propranolol hydrochloride vs Placebo

Design

RCT, Randomized, Double-blind, placebo-controlled

Follow-up

average of 25 months

Discussion

Member takes

Implication

Supports long-term propranolol post-MI to reduce recurrent coronary events; reinforces consensus for beta-blockers in secondary prevention.

Key Points

To evaluate the effectiveness of long-term propranolol administration in reducing recurrent myocardial infarction and coronary heart disease mortality.
Randomized, double-blind, placebo-controlled trial design
Involved 3,837 patients with a history of myocardial infarction followed for 25 months
Compared the incidence of coronary events between propranolol-treated and placebo groups.
Propranolol group experienced 10.0% coronary incidence versus 13.0% in placebo (23% reduction)
Definite nonfatal reinfarction was reduced by 15.6% in the propranolol group
Incidence of definite CHF was 14.8% for propranolol versus 12.6% for placebo.

Structured PICO

Does long-term administration of propranolol reduce coronary incidence in patients with a confirmed myocardial infarction?

Population

3,837 patients who had at least one confirmed myocardial infarction

Intervention

Propranolol hydrochloride (long-term administration)

Comparator

Placebo

Outcome

Coronary incidence (composite of recurrent nonfatal definite reinfarction plus fatal coronary heart disease) at an average of 25 monthscomposite

Long-term administration of propranolol significantly reduces the incidence of recurrent nonfatal reinfarction and fatal coronary heart disease in patients with a recent myocardial infarction.

Cite This Study

A 1983 study studied this question.

synapsesocial.com/papers/6a1bc57c1567d2fc4d5ef41e https://doi.org/10.1001/jama.1983.03340200048027

Topics

Heart failure HFrEF treatment

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Implication

Supports long-term propranolol post-MI to reduce recurrent coronary events; reinforces consensus for beta-blockers in secondary prevention.

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider