In a 40-year follow-up of rural men, age and pulse pressure were associated with increased stroke mortality, while physical activity and higher total serum cholesterol were protective.
These associations should not yet change stroke risk assessment; leaves open causal roles of pulse pressure and activity in prospective studies.
The present work evaluates several risk factors for stroke mortality based on a 40-year follow-up of the Corfu cohort from the Seven-Countries Study. The population studied in this analysis consisted of 529 rural men (49.7 +/- 5.7 years old) enrolled at 1961. The death rate at the end of follow-up was 87.1% (i.e. 461 deaths out of 529 participants). Of 529 cardiovascular-disease-free men at entry, 74 (14%) died because of hemorrhagic or thrombotic stroke. Age (HR=1.11/year, p<0.001), pulse pressure (HR=1.16/5 mm Hg, p<0.001), total serum cholesterol levels (HR=0.81/10 mg/dl, p<0.01) and presence of physical activity (HR=0.59, p<0.05), showed a statistically significant association with fatal stroke events. In conclusion, age, pulse pressure levels, physical activity (protective) and total serum cholesterol levels (protective) were significantly related with 40-year stroke mortality.
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Panagiotakos et al. (2003) studied this question.
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