Population
Normal and ischemic human kidneys
Comparison
Pulse-labeling experiments vs Normal human kidney tissue compared to ischemic…
Design
Preclinical
Authors
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Ischemia-induced renin processing changes remain animal-model specific; leaves open human validation before any clinical relevance.
The study elucidates the dual pathways of renin secretion in human kidneys and demonstrates that ischemia accelerates the processing of prorenin to mature renin.
Pratt et al. (1987) studied this question.
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