Why the study?
Does a blocker of the endothelin type A receptor prevent myocardial infarction in hypercholesterolemic apolipoprotein E-/- low density lipoprotein receptor-/- mice exposed to stress or hypoxia?
Population
Hypercholesterolemic apolipoprotein E-/- low density lipoprotein receptor-/- mice exposed to mental stress…
Design
Preclinical
Authors
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ET_A receptor blockade may protect against stress-induced myocardial injury in atherosclerotic mice; leaves open any human translation or clinical testing.
Does a blocker of the endothelin type A receptor prevent myocardial infarction in hypercholesterolemic apolipoprotein E-/- low density lipoprotein receptor-/- mice exposed to stress or hypoxia?
Endothelin type A receptor blockade prevents stress-induced myocardial infarction in a hypercholesterolemic mouse model of coronary atherosclerosis.
Caligiuri et al. (1999) studied this question.
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