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April 15, 2018Journal of Cardiovascular Pharmacology and TherapeuticsOpen Access

Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction

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Why the study?

Does colchicine reduce infarct size in a rat model of acute myocardial infarction?

Population

Rat model of acute myocardial infarction

Comparison

Colchicine administered per os 24 hours and… vs Vehicle

Design

Preclinical

Follow-up

120 minutes of reperfusion

Authors

OBOussama BakhtaSBSimon BlanchardAGAnne‐Laure Guihot

Discussion

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Overview

Colchicine pretreatment may attenuate early I/R injury via anti-inflammatory effects; leaves open optimal dosing and confirmation in larger trials.

Structured PICO

Does colchicine reduce infarct size in a rat model of acute myocardial infarction?

P
Population
Rat model of acute myocardial infarction (40-minute left anterior descending coronary occlusion followed by 120-minute reperfusion)
I
Intervention
Colchicine (0.3 mg/kg) administered per os 24 hours and immediately before surgery
C
Comparator
Vehicle
O
Outcome
Infarct sizesurrogate

Colchicine pretreatment reduces infarct size and modulates inflammatory markers in a rat model of acute myocardial ischemia/reperfusion injury.

Cite This Study

Bakhta et al. (2018) studied this question.

synapsesocial.com/papers/6a70f96435aa2c282ce24d74https://doi.org/10.1177/1074248418763611
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome2015 · 284 citations
  2. 2Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction2017 · 134 citations
  3. 3Colchicine disposition in human leukocytes after single and multiple oral administration1993 · 102 citations
  4. 4A Randomized Trial of Colchicine for Acute Pericarditis2013 · 614 citations
  5. 5Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low‐dose colchicine2008 · 111 citations