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April 27, 2025International ImmunopharmacologyOpen Access

Colchicine inhibits myocardial pyroptosis and reduces myocardial cell injury after myocardial infarction through the ESR1-PI3K-Akt-NF-κB signaling pathway

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Why the study?

The precise cardioprotective mechanisms underlying colchicine in limiting post-infarction cardiomyocyte injury remain incompletely elucidated.

Does colchicine reduce myocardial cell injury and pyroptosis in experimental models of myocardial infarction?

Comparison

Colchicine administration vs control in vivo and in vitro

Design

Preclinical in vivo and in vitro experimental study

Authors

SBShanQing BaoYDYijie DingGWG. Weng

Discussion

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Overview

Should not yet change post-MI practice; leaves open human validation of this cardiomyocyte-protective mechanism.

Structured PICO

Does colchicine reduce myocardial cell injury and pyroptosis in experimental models of myocardial infarction?

P
Population
Mice with permanent ligation of the left anterior descending coronary artery (LAD) and HL-1 mouse atrial cardiomyocytes treated with 0.3 mM H₂O₂
I
Intervention
Colchicine
O
Outcome
Myocardial injury, fibrosis, cardiac function, and cardiomyocyte pyroptosissurrogate

Colchicine attenuates post-infarction myocardial injury and pyroptosis in preclinical models via the ESR1-PI3K-Akt-NF-κB signaling pathway.

Cite This Study

Bao et al. (2025) studied this question.

synapsesocial.com/papers/6a80c1956b002de6d43fcdadhttps://doi.org/10.1016/j.intimp.2025.114732
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway2024 · 24 citations
  2. 2Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction2018 · 49 citations
  3. 3Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation2021 · 2 citations
  4. 4Colchicine Prevents Disease Progression in Viral Myocarditis Via Modulating the NLRP3 Inflammasome in the Cardiosplenic Axis2022 · 78 citations
  5. 5Novel Impact of Colchicine on Interleukin-10 Expression in Acute Myocardial Infarction: An Integrative Approach2024 · 6 citations