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September 4, 2015AJP Heart and Circulatory PhysiologyOpen Access

Induction of activating transcription factor 3 limits survival following infarct-induced heart failure in mice

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Why the study?

Does ATF3 deficiency improve survival in mice with infarct-induced heart failure?

Population

Wild-type and ATF3-null mice subjected to nonreperfused myocardial infarction to induce heart failure

Comparison

ATF3 deficiency (ATF3-null mice) vs Wild-type mice

Design

Preclinical

Follow-up

4 weeks

Authors

ABAlan C. BrooksADAngelica M. DeMartinoRBRobert E. Brainard

Discussion

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Overview

ATF3 induction post-MI in mice may affect remodeling; leaves open any therapeutic role in human heart failure.

Key Points

  • To determine the functional role of activating transcription factor 3 (ATF3) induction and nuclear translocation on cardiac remodeling and survival following myocardial infarction.
  • Subjected wild-type and ATF3-null mice to nonreperfused myocardial infarction to establish infarct-induced heart failure.
  • Evaluated survival rates, chamber dimensions, cardiac function, noninfarcted fibrosis, cardiomyocyte hypertrophy, and inflammatory markers at 2-week and 4-week post-infarction endpoints.
  • Nonreperfused myocardial infarction induced marked ATF3 expression and nuclear translocation in wild-type myocardium.
  • ATF3-null mice achieved significantly higher overall survival following infarct-induced heart failure compared with wild-type controls.
  • ATF3-null hearts displayed improved chamber dimensions, greater cardiomyocyte hypertrophy, and elevated fibrosis in noninfarcted regions at 2 weeks, with no persistent differences in cardiac function or inflammatory markers at 4 weeks.

Structured PICO

Does ATF3 deficiency improve survival in mice with infarct-induced heart failure?

P
Population
Wild-type and ATF3-null mice subjected to nonreperfused myocardial infarction to induce heart failure
I
Intervention
ATF3 deficiency (ATF3-null mice)
C
Comparator
Wild-type mice
O
Outcome
Survival following infarct-induced heart failurehard clinical

ATF3 deficiency improves survival following infarct-induced heart failure in mice, suggesting ATF3 plays a maladaptive role in heart failure.

Cite This Study

Brooks et al. (2015) studied this question.

synapsesocial.com/papers/6a70f96435aa2c282ce24d77https://doi.org/10.1152/ajpheart.00513.2015
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