Why the study?
Does immunization with cardiac troponin I exacerbate myocardial inflammation and cardiac dysfunction in mice following myocardial infarction or ischaemia reperfusion injury?
Does immunization with cardiac troponin I exacerbate myocardial inflammation and cardiac dysfunction in mice following myocardial infarction or ischaemia reperfusion injury?
Autoimmunity against cardiac troponin I exacerbates myocardial inflammation and cardiac dysfunction following both chronic myocardial infarction and ischaemia/reperfusion injury in a mouse model.
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cTnI autoimmunity worsens post-IR dysfunction in mice; hypothesis-generating for human MI inflammation, needs clinical validation.
Volz et al. (2011) studied this question.
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