April 27, 2004Circulation

Angiotensin II Type 2 Receptor–Mediated Vasodilation in Human Coronary Microarteries

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Population

Human coronary microarteries obtained from 49 heart valve donors

Comparison

Angiotensin II with or without AT1 receptor… vs Baseline or alternative antagonist conditions

Design

Preclinical

Authors

WBWendy W. BatenburgTerra IGIngrid M. GarreldsErasmus MC CBCatherine Chapuis BernasconiUniversity Hospital of Lausanne

Discussion

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Implication

AT2-mediated dilation in human coronary microarteries may merit exploration; leaves open therapeutic relevance pending in vivo confirmation.

Structured PICO

Population

Human coronary microarteries (diameter, 160 to 500 microm) obtained from 49 heart valve donors (age, 3 to 65 years)

Intervention

Angiotensin II with or without AT1 receptor antagonist (irbesartan), AT2 receptor antagonist (PD123319), NO synthase inhibitor (L-NAME), or B2 receptor antagonist (Hoe140)

Comparator

Baseline or alternative antagonist conditions

Outcome

Vasoconstriction and vasodilation responses measured in Mulvany myographssurrogate

AT2 receptor-mediated vasodilation in the human heart is present in coronary microarteries, is mediated by B2 receptors and NO, and its contribution increases with age.

Cite This Study

Batenburg et al. (2004) studied this question.

synapsesocial.com/papers/6a70fb0f75498292b70a778f https://doi.org/10.1161/01.cir.0000128696.12245.57

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Implication

AT2-mediated dilation in human coronary microarteries may merit exploration; leaves open therapeutic relevance pending in vivo confirmation.

Angiotensin II Type 2 Receptor–Mediated Vasodilation in Human Coronary Microarteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Type 2 Receptor–Mediated Vasodilation in Human Coronary Microarteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider