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March 19, 2014Modern Rheumatology

Abnormally thickened CIMT was observed in 27.5% of RA patients compared to 10% of control subjects (p = 0.04), with active disease being independently associated with thickened CIMT.

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Why the study?

Does rheumatoid arthritis increase the risk of subclinical atherosclerosis in patients without traditional cardiovascular risk factors?

Population

40 rheumatoid arthritis patients without any overt traditional cardiovascular risk factors, and 40 age- and…

Comparison

Rheumatoid arthritis (exposure) vs Age and gender matched healthy controls

Design

Case-control

Authors

NSNarisa Sulaiman SahariSSSyahrul Sazliyana ShaharirMIMohd Redzuan Ismail

Discussion

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Overview

Supports CV vigilance in active RA without traditional risks; leaves open causal role pending prospective data.

Structured PICO

Does rheumatoid arthritis increase the risk of subclinical atherosclerosis in patients without traditional cardiovascular risk factors?

P
Population
40 rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors, and 40 age- and gender-matched healthy controls.
I
Intervention
Rheumatoid arthritis (exposure)
C
Comparator
Age and gender matched healthy controls
O
Outcome
Subclinical atherosclerosis measured as abnormally thickened carotid intima media thickness (CIMT) (>75th percentile matched for age and sex)surrogate

Rheumatoid arthritis patients without traditional cardiovascular risk factors have a significantly higher prevalence of subclinical atherosclerosis, particularly those with active disease.

Cite This Study

Sahari et al. (2014) studied this question.

synapsesocial.com/papers/6a70fb8a53da1ffdb507b143https://doi.org/10.3109/14397595.2014.891497
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