Why the study?
Does normothermic cardiopulmonary bypass compared to hypothermic cardiopulmonary bypass alter nitric oxide release in patients undergoing coronary bypass surgery?
Population
40 patients (mean age 61.4 +/- 8.4 years) undergoing coronary bypass surgery.
Comparison
Systemic normothermic cardiopulmonary bypass… vs Systemic hypothermic CPB and antegrade cold…
Design
Cohort
Follow-up
60 minutes after the end of CPB
Authors
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Normothermia during CPB was associated with higher nitrite levels; leaves open whether temperature modulation influences outcomes in coronary bypass.
Does normothermic cardiopulmonary bypass compared to hypothermic cardiopulmonary bypass alter nitric oxide release in patients undergoing coronary bypass surgery?
Cardiopulmonary bypass induces a progressive increase in nitric oxide release, which is more pronounced under normothermic compared to hypothermic conditions.
Ruvolo et al. (1995) studied this question.
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