Population
17 sheep with miniature radiopaque markers sewn to the mitral valve annulus, anterior leaflet, and papillary…
Design
Preclinical
Authors
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Indicates active contractile effects may augment ovine mitral leaflet stiffness; leaves open translation to human valve modeling or repair.
In vivo material properties of the ovine mitral valve anterior leaflet are significantly greater than in vitro estimates, potentially due to active contractile tissue.
Krishnamurthy et al. (2008) studied this question.
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