April 17, 2010AJP Heart and Circulatory PhysiologyOpen Access

Transient stiffening of mitral valve leaflets in the beating heart

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Population

10 ovine hearts (30 beats analyzed)

Comparison

Measurement of circumferential and radial… vs Comparison across different phases of the…

Design

Preclinical

Authors

GKGaurav KrishnamurthyPalo Alto Institute AIAkinobu ItohBrigham and Women's Hospital JSJulia C. SwansonWashington University in St. Louis

Discussion

Member takes

Implication

Animal data implicate active myocyte force in mitral leaflet stiffening during contraction; leaves open relevance to human valve function.

Structured PICO

Population

10 ovine hearts (30 beats analyzed)

Intervention

Measurement of circumferential and radial stiffness using radiopaque markers and inverse finite element analysis

Comparator

Comparison across different phases of the cardiac cycle (isovolumic contraction, midsystole, isovolumic relaxation)

Outcome

Circumferential (E(c)) and radial (E(r)) stiffness during different phases of ventricular systolesurrogate

Anterior mitral leaflet stiffening during isovolumic contraction appears to arise primarily from transient force development in leaflet cardiac myocytes.

Cite This Study

Krishnamurthy et al. (2010) studied this question.

synapsesocial.com/papers/6a9094e4039ece43b30d5ab1 https://doi.org/10.1152/ajpheart.00215.2010

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Implication

Animal data implicate active myocyte force in mitral leaflet stiffening during contraction; leaves open relevance to human valve function.

Transient stiffening of mitral valve leaflets in the beating heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transient stiffening of mitral valve leaflets in the beating heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider