Why the study?
Does basal interventricular-septal pacing without atrial contraction reduce anterior leaflet stiffening during isovolumic contraction in a sheep model?
Population
10 sheep with radioopaque-marker arrays implanted in the left ventricle, mitral annulus, anterior leaflet…
Comparison
Basal interventricular-septal pacing to generate… vs Baseline with normal atrial depolarization
Design
Preclinical
Authors
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May explain mitral regurgitation worsening with ventricular pacing or heart block; leaves open translation to human valve function.
Does basal interventricular-septal pacing without atrial contraction reduce anterior leaflet stiffening during isovolumic contraction in a sheep model?
Anterior leaflet annular stiffening during isovolumic contraction requires atrial depolarization, providing a mechanistic explanation for why heart block or ventricular pacing may worsen mitral regurgitation.
Swanson et al. (2011) studied this question.
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