Why the study?
Does acute left atrial and ventricular ischemia alter atrial contraction, mitral annular dynamics, and mitral regurgitation in a sheep model?
Population
Six sheep with radiopaque markers placed on the left ventricle, mitral annulus, left atrium, and mitral…
Comparison
Acute ischemia induced by balloon occlusion of… vs Baseline (before balloon occlusion)
Design
Preclinical
Authors
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Acute posterolateral ischemia may induce MR via atrial mechanisms in sheep; leaves open translation to human ACS.
Does acute left atrial and ventricular ischemia alter atrial contraction, mitral annular dynamics, and mitral regurgitation in a sheep model?
Acute posterolateral ischemia decreases atrial contractile function, which diminishes presystolic mitral annular reduction and leads to mitral regurgitation.
Timek et al. (2002) studied this question.
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