Population
10 sheep with radiopaque markers placed in the left atrium, mitral annulus, and left ventricular base
Comparison
Acute volume depletion via inferior vena caval… vs Normal physiological conditions before occlusion
Design
Preclinical
Follow-up
12 weeks postoperatively
Authors
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May inform mitral valve repair in hypovolemia; leaves open translation from animal models to clinical practice.
Presystolic mitral annular septal-lateral shortening is independent of left atrial and left ventricular dynamics during acute volume depletion, providing physiological insights that may inform mitral valve repair strategies.
Bothe et al. (2009) studied this question.
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