Why the study?
Does phenol ablation of the mitral annulus and anterior mitral leaflet muscle alter mitral annular and leaflet dynamics in sheep?
Population
18 sheep with radiopaque markers sutured to the left ventricle, mitral annulus, and both mitral leaflets
Comparison
Phenol applied circumferentially to the atrial… vs Control sheep without phenol ablation (n=8)
Design
Preclinical
Authors
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Implicates atrial myocardial fibers in mitral annular dynamics; hypothesis-generating in sheep and leaves open human translation.
Does phenol ablation of the mitral annulus and anterior mitral leaflet muscle alter mitral annular and leaflet dynamics in sheep?
Myocardial fibers on the atrial side of the mitral valve actively influence the 3-D dynamic geometry and shape of the mitral annulus and anterior mitral leaflet.
Timek et al. (2003) studied this question.
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