A Highly Efficient Aminohydroxylation Process

In the absence of external ligands α,β-unsaturated amides represent one of the few olefin classes which exhibit excellent rates and yields in osmium-catalyzed aminohydroxylation. The scope of the reaction was examined, and a one-pot method for the conversion of the hydroxysulfonamides 2 and 3 into the corresponding aziridines 4 developed. Ts = p-MeC6H4SO2.