Why the study?
Does the combination of curcumin and nebivolol improve doxorubicin-induced cardiac toxicity in rats compared to monotherapy?
Population
Male rats with doxorubicin-induced cardiac toxicity (induced by intraperitoneal injection over 23 days)
Comparison
Oral administration of curcumin, nebivolol, and… vs Control group and monotherapy groups
Design
Preclinical
Follow-up
23 days
Authors
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May support rat-model cardioprotection against doxorubicin; hypothesis-generating and should not change practice.
Does the combination of curcumin and nebivolol improve doxorubicin-induced cardiac toxicity in rats compared to monotherapy?
The combination of low-dose curcumin and nebivolol provides synergistic cardioprotection against doxorubicin-induced toxicity in a rat model.
Imbaby et al. (2014) studied this question.
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