Why the study?
What is the relationship between inogatran plasma concentration and APTT in healthy subjects and patients with coronary artery disease?
Population
78 healthy males from 5 phase I studies and 948 patients of both sexes with unstable angina pectoris or…
Authors
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CAD patients may need higher inogatran doses for target anticoagulation; leaves open efficacy questions for later-phase trials.
What is the relationship between inogatran plasma concentration and APTT in healthy subjects and patients with coronary artery disease?
Inogatran exhibits a nonlinear concentration-effect relationship on APTT, with patients with coronary artery disease showing lower baseline APTT and a less pronounced anticoagulant effect compared to healthy subjects.
Cullberg et al. (2001) studied this question.
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