November 1, 1990Circulation Research

Mechanism of adenosine-induced inhibition of calcium current in guinea pig ventricular cells.

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Population

Isolated guinea pig ventricular cells (n=7 patches)

Comparison

0.1 mM adenosine added to superfusate in the… vs Control (100 nM isoproterenol alone)

Design

Preclinical

Authors

MKMasashi KatoNagara Medical Center HYHiroshi YamaguchiKobe University RORikuo OchiNew York Medical College

Discussion

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Implication

Suggests adenosine counters beta-adrenergic calcium current enhancement in ventricular myocytes; leaves open applicability to human cardiac electrophysiology.

Structured PICO

Population

Isolated guinea pig ventricular cells (n=7 patches)

Intervention

0.1 mM adenosine added to superfusate in the presence of 100 nM isoproterenol

Comparator

Control (100 nM isoproterenol alone)

Outcome

Single-channel Ca2+ currents (peak amplitude, open probability, and channel availability)surrogate

Adenosine decreases calcium current under beta-adrenergic stimulation in guinea pig ventricular cells primarily by reducing channel availability.

Cite This Study

Kato et al. (1990) studied this question.

synapsesocial.com/papers/6a70fe5a26a7f98052dd6e1e https://doi.org/10.1161/01.res.67.5.1134

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Implication

Suggests adenosine counters beta-adrenergic calcium current enhancement in ventricular myocytes; leaves open applicability to human cardiac electrophysiology.

Mechanism of adenosine-induced inhibition of calcium current in guinea pig ventricular cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of adenosine-induced inhibition of calcium current in guinea pig ventricular cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider