What question did this study set out to answer?

To assess microalbuminuria prevalence in hypertensive individuals and its associations with cardiovascular damage and renal dysfunction.

July 1, 1996Journal of Hypertension

Microalbuminuria, renal dysfunction and cardiovascular complication in essential hypertension

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Population

383 hospitalized Caucasian essential hypertensives, mean age 44 +/- 0.5 years, mean clinic blood pressure…

Design

Cross-sectional

Authors

GCGiovanni CerasolaApple (Israel)SCSantina CottoneEuropean Society of Hypertension GMGiuseppe MulèGeneral Cardiology

Discussion

Member takes

Implication

Microalbuminuria may flag subclinical organ damage in hypertension; hypothesis-generating and should not yet change practice.

Key Points

To assess microalbuminuria prevalence in hypertensive individuals and its associations with cardiovascular damage and renal dysfunction.
Transversal study involving 383 Caucasian essential hypertensives
Measured metabolic parameters, serum creatinine, 24-hour AER, and performed echocardiography
Divided subjects into three groups based on AER levels
55% of patients had AER < 11 micrograms/min, 18% between 11-20 micrograms/min, and 27% > 20 micrograms/min
Left ventricular hypertrophy prevalence was 44.39%, with hypertensive retinopathy at 54.83%
Group C had significantly higher clinic SBP, 24h SBP/DBP, and prevalence of left ventricular hypertrophy (55%) and retinopathy (69%) compared to group A.

Structured PICO

Population

383 hospitalized Caucasian essential hypertensives (198 men, 185 women), mean age 44 +/- 0.5 years, mean clinic blood pressure 170.3 +/- 0.95/ 103.4 +/- 0.47 mmHg.

Outcome

Microalbuminuria, creatinine clearance, PRA, ABPM, LVMI, LVMH, early:late peak filling velocity ratio, hypertensive retinopathysurrogate

Microalbuminuria serves as an early marker of cardiac, renal, and retinal structural and functional changes in essential hypertension.

Cite This Study

Cerasola et al. (1996) studied this question.

synapsesocial.com/papers/6a70fe9ea528af2d65c3da4d https://doi.org/10.1097/00004872-199607000-00016

Topics

Hypertension management

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