Drug treatment of hypertension: implications of ALLHAT
Why the study?
Does lisinopril compared to atenolol better reduce arterial stiffness in patients on hemodialysis?
Population
179 patients on hemodialysis with valid assessment of aortic pulse wave velocity at baseline
Comparison
Open-label lisinopril three times a week after… vs Open-label atenolol three times a week after…
Design
RCT, Randomly assigned, Open-label
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Atenolol's PWV advantage over lisinopril in hemodialysis is BP-mediated; confirms BP reduction, not drug class, as the primary driver of arterial stiffness change.
Structured PICO
Does lisinopril compared to atenolol better reduce arterial stiffness in patients on hemodialysis?
P
Population
179 patients on hemodialysis with valid assessment of aortic pulse wave velocity at baseline (from the Hypertension in Hemodialysis Patients Treated with Atenolol or Lisinopril Trial)
I
Intervention
Open-label lisinopril three times a week after dialysis
C
Comparator
Open-label atenolol three times a week after dialysis
O
Outcome
Percentage change of aortic pulse wave velocity from baseline to 6 monthssurrogate
In hemodialysis patients, atenolol was superior to lisinopril in improving arterial stiffness, though this difference appeared to be driven by blood pressure-lowering effects.
Cite This Study
Bryan Williams (2003) studied this question.