February 23, 2017Journal of Medical VirologyOpen Access

Characterization of genome sequences and clinical features of coxsackievirus A6 strains collected in Hyogo, Japan in 1999‐2013

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Population

5,612 children with suspected enterovirus infection between 1999 and 2013 in Hyogo Prefecture, Japan, of…

Design

Cohort

Authors

MOMiki OgiHyogo Prefectural Institute of Environmental Sciences YYYoshihiko YanoKobe University Hospital MCMasatsugu ChikahiraHyogo Prefectural Institute of Environmental Sciences

Discussion

Member takes

Implication

Genomic evolution in CV-A6 may signal shifting pediatric manifestations; leaves open whether specific mutations drive HFMD outbreaks.

Structured PICO

Population

5,612 children (0-17 years old) with suspected enterovirus infection between 1999 and 2013 in Hyogo Prefecture, Japan, of whom 127 were positive for CV-A6.

Outcome

Association of CV-A6 genomic sequences with clinical manifestations (herpangina vs hand, foot, and mouth disease)

Recent hand, foot, and mouth disease outbreaks in Japan caused by CV-A6 are associated with a distinct genomic cluster compared to older strains that primarily caused herpangina.

Cite This Study

Ogi et al. (2017) studied this question.

synapsesocial.com/papers/6a70fee9e5469ee92be1a464 https://doi.org/10.1002/jmv.24798

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Characterization of genome sequences and clinical features of coxsackievirus A6 strains collected in Hyogo, Japan in 1999‐2013

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of genome sequences and clinical features of coxsackievirus A6 strains collected in Hyogo, Japan in 1999‐2013

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider