What question did this study set out to answer?

The study aims to investigate the remodeling of coronary microcirculation in patients with idiopathic dilated cardiomyopathy (IDCM).

January 1, 2011Cardiology

Coronary Microcirculation Remodeling in Patients with Idiopathic Dilated Cardiomyopathy

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Population

Explanted hearts of 6 patients with idiopathic dilated cardiomyopathy and 6 normal control hearts

Design

Case-control

Authors

RLRubén P. LaguensFavaloro University PÁPaulino ÁlvarezCleveland Clinic CVCarlos ViglianoConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

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Implication

Arteriolar rarefaction in IDCM should not yet guide therapy; leaves open its role in impaired coronary flow reserve.

Key Points

The study aims to investigate the remodeling of coronary microcirculation in patients with idiopathic dilated cardiomyopathy (IDCM).
Examined explanted hearts from 6 IDCM patients and 6 normal control hearts.
Measured arteriolar length density and capillary numerical density in vascular sections stained for smooth muscle actin and CD34.
Focused on vessels with diameters of 50-200 μm and 6-50 μm.
In IDCM, more than 50% of arterioles below 50 μm in diameter had an incomplete smooth muscle wall.
Length density for arterioles between 6 and 20 μm was significantly lower in IDCM (42.84 ± 8.51 mm/mm(3)) compared to controls (75.34 ± 3.05 mm/mm(3), p = 0.001).
No significant difference in capillary numerical density was found between IDCM and normal hearts.

Structured PICO

Population

Explanted hearts of 6 patients with idiopathic dilated cardiomyopathy (IDCM) and 6 normal control hearts (n=12)

Comparator

Normal control hearts

Outcome

Arteriolar length density and capillary numerical densitysurrogate

Patients with idiopathic dilated cardiomyopathy exhibit a significant decrease in the length density of small arterioles, providing an anatomical basis for decreased coronary flow reserve.

Cite This Study

Laguens et al. (2011) studied this question.

synapsesocial.com/papers/6a70ff53e36a167817e2d3c9 https://doi.org/10.1159/000331440

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Coronary Microcirculation Remodeling in Patients with Idiopathic Dilated Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary Microcirculation Remodeling in Patients with Idiopathic Dilated Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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