What question did this study set out to answer?

Investigate vascular abnormalities, microvessel density, and vessel formation mechanisms in patients with idiopathic dilated cardiomyopathy.

August 28, 2007European Journal of Heart Failure

Idiopathic Dilated Cardiomyopathy Exhibits Defective Vascularization and Vessel Formation

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Why the study?

Do patients with idiopathic dilated cardiomyopathy exhibit defective vascularization and vessel formation compared to controls?

Population

Patients with idiopathic dilated cardiomyopathy (IDCM) and controls

Design

Case-control

Authors

SRSantiago RouraUniversitat de Vic - Universitat Central de Catalunya FPFrancesc PlanasHospital Municipal de Badalona CPCristina Prat‐VidalBanc de Sang i Teixits

Discussion

Member takes

Implication

Hypoxia-associated progenitor mobilization in IDCM suggests ineffective angiogenesis; hypothesis-generating for beta-catenin or HIF-1alpha modulation.

Key Points

Investigate vascular abnormalities, microvessel density, and vessel formation mechanisms in patients with idiopathic dilated cardiomyopathy.
Assessed epicardial coronary artery dimensions in patients with idiopathic dilated cardiomyopathy and controls using multi-slice CT.
Quantified circulating cytokines and endothelial progenitor cells using flow cytometry and endothelial colony formation assays.
Analyzed myocardial microvessel density and the expression of HIF-1alpha and beta-catenin using immunohistochemistry and Western blot.
Epicardial coronary arteries were shorter and narrower with reduced microvascular density and increased HIF-1alpha(+) cells in IDCM (46.8±13.1% vs. 19.4±9.4%, p=0.006).
Circulating VEGF-A levels were elevated (394 pg/mL vs. 22 pg/mL, p=0.001) alongside a 21-fold increase in CD133(+)/VEGF-R2(+) mobilized progenitors (6.5±3.3% vs. 0.3±0.2%, p<0.001).
Myocardial expression of vascular beta-catenin was reduced in IDCM, marking an impairment in downstream angiogenic pathways.

Structured PICO

Do patients with idiopathic dilated cardiomyopathy exhibit defective vascularization and vessel formation compared to controls?

Population

Patients with idiopathic dilated cardiomyopathy (IDCM) and controls

Comparator

Controls

Outcome

Epicardial vasculature length and diameter, microvascular density, mobilizing cytokines, circulating endothelial progenitor cells (EPCs), and expression of HIF-1alpha and beta-cateninsurrogate

Patients with idiopathic dilated cardiomyopathy demonstrate defective vascularization, impaired vasculogenesis, and angiogenesis, which is associated with local epicardial hypoxia and reduced beta-catenin expression.

Cite This Study

Roura et al. (2007) studied this question.

synapsesocial.com/papers/6a7395a87af34f94aaa731f0 https://doi.org/10.1016/j.ejheart.2007.07.008

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Implication

Hypoxia-associated progenitor mobilization in IDCM suggests ineffective angiogenesis; hypothesis-generating for beta-catenin or HIF-1alpha modulation.

Idiopathic Dilated Cardiomyopathy Exhibits Defective Vascularization and Vessel Formation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Idiopathic Dilated Cardiomyopathy Exhibits Defective Vascularization and Vessel Formation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider