Population
Myocardial tissue from patients with dilated cardiomyopathy, ischemic cardiomyopathy, and control subjects…
Comparison
RNA interference against VE-cadherin and VEGF… vs Ischemic cardiomyopathy tissue, control tissue…
Design
Preclinical
Authors
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Animal findings implicate endothelial pathways in DCM; leaves open human relevance and therapeutic targeting.
Impaired VE-cadherin/beta-catenin expression mediates endothelial cell degeneration in dilated cardiomyopathy, suggesting a potential therapeutic target.
Schäfer et al. (2003) studied this question.
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