Why the study?
Does intramyocardial injection of plasmid DNA encoding VEGF improve cardiac function and microvascular homeostasis in a streptozotocin-induced diabetic rat model?
Population
Streptozotocin-induced diabetic rat model
Design
Preclinical
Follow-up
1 year
Authors
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Hypothesis-generating for VEGF gene therapy in diabetic cardiomyopathy; human trials required before any clinical consideration.
Does intramyocardial injection of plasmid DNA encoding VEGF improve cardiac function and microvascular homeostasis in a streptozotocin-induced diabetic rat model?
Downregulation of VEGF is a seminal event in diabetic cardiomyopathy, and targeted VEGF gene therapy can restore microvascular homeostasis and improve cardiac function in a preclinical model.
Yoon et al. (2005) studied this question.
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