What question did this study set out to answer?

To measure lidocaine concentrations in follicular fluid following paracervical block and determine whether exposure influences fertilization, early embryo cleavage, or pregnancy rates.

November 1, 1990Human Reproduction

The concentration of lidocaine in follicular fluid when used for paracervical block in a human IVF-ET programme

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Authors

MWMatts WiklandUniversity of Gothenburg HEHans EversUniversity of Helsinki AJAnn‐Helene JakobssonUniversity of Gothenburg

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Implication

Controlled study reveals follicular lidocaine exposure does not impair fertilization or pregnancy rates in IVF patients, suggesting paracervical block safety.

Key Points

To measure lidocaine concentrations in follicular fluid following paracervical block and determine whether exposure influences fertilization, early embryo cleavage, or pregnancy rates.
Assessed 92 women undergoing transvaginal follicle aspiration, comparing those receiving paracervical block with 50 mg lidocaine (n=46) to an unblocked control group (n=46).
Quantified lidocaine concentration in aspirated follicular fluid and tracked subsequent fertilization, cleavage, and pregnancy rates between groups.
Mean lidocaine concentration in follicular fluid after paracervical block was 0.36 ± 1.1 µg/ml.
Lidocaine concentrations did not differ significantly between follicles yielding fertilized versus unfertilized oocytes.
Fertilization, cleavage, and pregnancy rates showed no significant differences between women receiving lidocaine paracervical block and untreated controls.

Cite This Study

Wikland et al. (1990) studied this question.

synapsesocial.com/papers/6a70ff67ac440176ef29accd https://doi.org/10.1093/oxfordjournals.humrep.a137220

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Implication

Controlled study reveals follicular lidocaine exposure does not impair fertilization or pregnancy rates in IVF patients, suggesting paracervical block safety.

The concentration of lidocaine in follicular fluid when used for paracervical block in a human IVF-ET programme

Discussion

Member takes

Implication

Key Points

Cite This Study

The concentration of lidocaine in follicular fluid when used for paracervical block in a human IVF-ET programme

Discussion

Member takes

Implication

Key Points

Cite This Study

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