Why the study?
Does preeclampsia alter the pharmacokinetics of epidural lidocaine in women undergoing cesarean section compared to normotensive women?
Population
15 women (10 preeclamptic, 5 normotensive) undergoing cesarean section at 36-40 weeks of gestation
Comparison
Lumbar epidural anesthesia using 15-20 ml of 2%… vs Normotensive women undergoing cesarean section
Design
Cohort
Follow-up
Up to 24 hours after birth
Authors
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May warrant lidocaine dose caution in preeclamptic cesarean sections; hypothesis-generating and requires prospective validation before practice change.
Does preeclampsia alter the pharmacokinetics of epidural lidocaine in women undergoing cesarean section compared to normotensive women?
Total maternal body clearance of epidural lidocaine is prolonged in preeclampsia, suggesting that repeated administration may lead to higher blood levels compared to normotensive patients.
Heikkilä et al. (1986) studied this question.
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