Why the study?
Does PCR testing of nasopharyngeal specimens detect parechovirus or enterovirus in infants evaluated for late-onset sepsis in the NICU?
Does PCR testing of nasopharyngeal specimens detect parechovirus or enterovirus in infants evaluated for late-onset sepsis in the NICU?
Parechovirus and enterovirus were not detected in nasopharyngeal specimens of infants evaluated for late-onset sepsis in the NICU, suggesting these viruses may not be common causes in this specific setting.
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Absence of parechovirus/enterovirus by nasopharyngeal PCR does not support routine testing in late-onset neonatal sepsis; leaves open their etiologic role and optimal diagnostics.
In a prospective cohort study of 65 inborn infants who were evaluated for late-onset sepsis at >72 hours of age in 2 academic neonatal intensive care units, none had parechovirus or enterovirus RNA detected by polymerase chain reaction performed on nasopharyngeal specimens during the first or subsequent sepsis evaluations (n = 80).
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Sánchez et al. (2022) studied this question.
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