Key result
Genetic CAD risk assessments inform clinical decisions, but trial data demonstrating event reduction remain lacking.
Understanding the genetic basis of coronary artery disease (CAD) can improve management and prevention. Family and twin studies, animal models and gene association studies support a genetic basis for CAD. Genes contribute to CAD development and progression, and response to risk factor modification and lifestyle choices. Family history is the best indicator of a predisposition to CAD and further refinement is possible with biochemical and DNA testing. Many inherited cardiovascular risk factors can be modified, such as LDL cholesterol, homocysteine and lipoprotein(a). Early detection of CAD might lead to earlier intervention for genetically susceptible individuals. However, data are lacking regarding the efficacy of this approach in preventing clinical events. Despite this lack of evidence, knowledge of genetic CAD susceptibility has value in providing risk information and guiding decision making. Further research that investigates outcomes regarding genetic risk assessment for CAD is necessary.
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Maren T. Scheuner (2001) conducted a review in Coronary artery disease (CAD). Genetic predisposition and risk assessment for coronary artery disease was evaluated on Prevention of clinical events. Genetic predisposition to CAD, assessed via family history and DNA/biochemical testing, guides risk decisions, though efficacy data for preventing clinical events are lacking.
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