Why the study?
Do the ANGPTL4 E40K and T266M variants affect plasma triglyceride levels and the risk of coronary heart disease?
Population
13,527 individuals across 5 studies, including a specific cohort of 2,772 men, and a subset of 332…
Comparison
Presence of ANGPTL4 genetic variants vs Non-carriers of the ANGPTL4 variants
Design
Meta-analysis
Authors
Loading...
Paradoxical CHD risk elevation despite lower triglycerides with E40K; leaves open non-lipid mechanisms and should not yet guide ANGPTL4-targeted therapy.
Do the ANGPTL4 E40K and T266M variants affect plasma triglyceride levels and the risk of coronary heart disease?
Although the ANGPTL4 E40K variant is associated with an atheroprotective lipid profile (lower triglycerides), it paradoxically increases the risk of coronary heart disease, suggesting effects beyond lipid modulation.
Talmud et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: