September 10, 2010Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

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Population

2,775 subjects from the Northwick Park Heart Study II, plus a meta-analysis of 5 studies, and in vitro human…

Design

Cohort

Authors

MSMelissa SmartUniversity of Essex MRMarius R. RobciucUniversity of Helsinki JCJackie A. CooperGeneral / Preventive / Lipids

Discussion

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Implication

Does not support Angptl4 as causal for triglycerides or CHD; leaves open its role in other pathways.

Structured PICO

Population

2,775 subjects from the Northwick Park Heart Study II (666 with quantified plasma Angptl4), plus a meta-analysis of 5 studies (4,061 cases/15,395 controls), and in vitro human embryonic kidney 293 and human hepatoma 7 cells.

Outcome

Relationship between plasma Angptl4 levels, triglycerides, CHD risk, and ANGPTL4 variants (T266M, E40K)surrogate

Circulating Angptl4 levels do not appear to influence triglyceride levels or coronary heart disease risk, providing new insights into its role in lipid metabolism.

Cite This Study

Smart et al. (2010) studied this question.

synapsesocial.com/papers/6a7f8efefb3b41a99728bde5 https://doi.org/10.1161/atvbaha.110.212209

Topics

Coronary artery disease

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The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider