Associations between Common Genetic Polymorphisms in Angiopoietin-Like Proteins 3 and 4 and Lipid Metabolism and Adiposity in European Adolescents and Adults
Key result
The ANGPTL3 rs11207997 polymorphism was associated with lower plasma HDL-cholesterol and apolipoprotein A-I levels in both adolescents (P=0.0004) and adults (P=0.03).
Why the study?
Do ANGPTL3 and ANGPTL4 genetic polymorphisms influence lipid metabolism and adiposity in European adolescents and adults?
Population
2,299 participants from two independent population-based studies: 1,144 adolescents from nine European…
Comparison
ANGPTL3 and ANGPTL4 genetic polymorphisms vs Alternative alleles/genotypes
Design
Cross-sectional
Authors
Discussion
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Implication
ANGPTL3 variant tied to lower HDL-C from adolescence; hypothesis-generating for lipid effects, needs prospective studies before any clinical role.
Study Design
Type
Observational (n=2,299)
Multicenter
Yes
Structured PICO
Do ANGPTL3 and ANGPTL4 genetic polymorphisms influence lipid metabolism and adiposity in European adolescents and adults?
P
Population
2,299 adolescents and adults from two independent European population-based studies evaluated for associations between ANGPTL3 and ANGPTL4 polymorphisms and metabolic phenotypes.
E
Exposure
ANGPTL3 (rs11207997) and ANGPTL4 (rs4076317) genetic polymorphisms
C
Comparator
Alternative alleles/genotypes
O
Outcome
Lipid metabolism (plasma HDL-cholesterol and apolipoprotein A-I levels) and adiposity (percentage of body fat, waist-to-hip ratio)surrogate
Main Result
p-value: p=0.0004
Genetic variations in ANGPTL3 are associated with HDL-cholesterol metabolism starting in adolescence, while ANGPTL4 polymorphisms may influence body fat distribution.
Limitations
- Findings regarding ANGPTL4 polymorphisms and body fat require replication
- Findings regarding ANGPTL4 require replication
Cite This Study
Legry et al. (2009) conducted an observational in Lipid metabolism and adiposity (n=2,299). ANGPTL3 and ANGPTL4 genetic polymorphisms was evaluated on Plasma HDL-cholesterol and apolipoprotein A-I levels (p=0.0004). The ANGPTL3 rs11207997 polymorphism was associated with lower plasma HDL-cholesterol and apolipoprotein A-I levels in both adolescents (P=0.0004) and adults (P=0.03).