Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits
Why the study?
Are plasma ANGPTL3 and ANGPTL4 concentrations associated with lipid and metabolic traits in a community-based sample?
Population
1770 subjects from a community-based sample
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Cross-sectional ANGPTL3/4–lipid associations should not guide therapy; leaves open causal roles and outcome prediction in community cohorts.
Structured PICO
Are plasma ANGPTL3 and ANGPTL4 concentrations associated with lipid and metabolic traits in a community-based sample?
P
Population
1770 subjects from a community-based sample
I
Intervention
Measurement of plasma ANGPTL3 and ANGPTL4 concentrations
O
Outcome
Association with lipid traits (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides) and metabolic traits (fasting blood glucose, metabolic syndrome)surrogate
Despite similar in vitro effects, plasma ANGPTL3 and ANGPTL4 have divergent relationships with plasma lipids and metabolic syndrome traits in vivo.
Cite This Study
Mehta et al. (2014) studied this question.