Key result
Obesity with altered glucose tolerance was associated with significantly increased ANGPTL-4 levels compared to lean participants, and levels decreased with weight loss over 2 years.
Why the study?
Are circulating ANGPTL-4 levels associated with obesity and altered glucose tolerance, and do they change with weight loss?
Population
333 participants across two cohorts: 282 lean and obese patients with normoglycemia or altered glucose…
Comparison
Hypocaloric diet vs Lean participants; participants losing weight vs…
Design
Cohort
Follow-up
2 years (for longitudinal cohort)
Authors
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ANGPTL-4 may mark metabolic dysfunction in obesity; observational data leave open causal role and clinical utility.
Observational (n=333)
Are circulating ANGPTL-4 levels associated with obesity and altered glucose tolerance, and do they change with weight loss?
Circulating ANGPTL-4 levels are elevated in obesity with altered glucose tolerance and track with long-term body weight changes, suggesting a role in metabolic regulation.
Barja-Fernández et al. (2018) conducted an observational in Obesity and altered glucose tolerance (n=333). Obesity, altered glucose tolerance, and weight change vs. Lean participants and weight loss was evaluated on Circulating ANGPTL-4 levels. Obesity with altered glucose tolerance was associated with significantly increased ANGPTL-4 levels compared to lean participants, and levels decreased with weight loss over 2 years.
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