Population
Pulmonary angiotensin I-converting enzymes purified to electrophoretic homogeneity from four mammalian…
Design
Preclinical
Authors
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Supports extrapolation of ACE inhibitor kinetics from animals to humans; leaves open clinical relevance of mixed-type differences.
ACE inhibitors demonstrate mixed-type inhibition with identical kinetic parameters across mammalian species, supporting the extrapolation of animal model results to humans.
Baudin et al. (1999) studied this question.
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