Why the study?
Is myeloperoxidase gene variation associated with carotid atherosclerosis in patients with essential hypertension?
Is myeloperoxidase gene variation associated with carotid atherosclerosis in patients with essential hypertension?
The MPO gene polymorphism (GC genotype) is associated with a higher frequency of carotid atherosclerosis in patients with essential hypertension.
MPO GC genotype association with carotid atherosclerosis in hypertension is hypothesis-generating; prospective validation required before any clinical consideration.
The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the occurrence of plaque in the carotid artery in the AS group was higher compared to the non-AS group. The frequency of the GC genotype in the AS group was significantly higher compared to the non-AS group. The frequency of carotid AS is higher in patients with hypertension, which is related to the MPO gene polymorphism.
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JinRui et al. (2012) studied this question.
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