Why the study?
Does the time of levofloxacin administration affect the extent of QTc prolongation in healthy male subjects?
Does the time of levofloxacin administration affect the extent of QTc prolongation in healthy male subjects?
The time of drug administration significantly influences the extent of levofloxacin-induced QTc prolongation, suggesting that 24-hour variation could confound drug safety assessments.
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Dosing time may modulate levofloxacin QTc effects in healthy volunteers; leaves open translation to patient chronotherapy trials.
Kervezee et al. (2016) studied this question.
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