January 1, 1990AJP Cell Physiology

Ca2(+)-induced Ca2+ release as examined by photolysis of caged Ca2+ in single ventricular myocytes

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Population

Isolated whole cell clamped guinea pig ventricular myocytes dialyzed with unphotolyzed DM-nitrophen

Comparison

Photorelease of Ca2+ via a 160-microseconds… vs Myocytes pretreated with caffeine

Design

Preclinical

Authors

MNMichael NäbauerInterventional / Structural Cardiology MMMartin MoradElectrophysiology

Discussion

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Implication

Animal data affirm intracellular Ca2+ release for myocyte contraction; leaves open translation to human cardiac disease.

Structured PICO

Population

Isolated whole cell clamped guinea pig ventricular myocytes dialyzed with unphotolyzed DM-nitrophen

Intervention

Photorelease of Ca2+ via a 160-microseconds light pulse on caged Ca2+ compound DM-nitrophen

Comparator

Myocytes pretreated with caffeine

Outcome

Activation of contractionsurrogate

Direct photorelease of Ca2+ in intact mammalian cardiac myocytes confirms that Ca2+ release from intracellular pools is necessary to generate tension.

Limitations

Intracellular Ca2+ concentration may not have risen sufficiently to inactivate the release channel, preventing definitive rejection of the Ca2+-induced inactivation hypothesis.

Cite This Study

Näbauer et al. (1990) studied this question.

synapsesocial.com/papers/6a71016575498292b70a7d8e https://doi.org/10.1152/ajpcell.1990.258.1.c189

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Ca2(+)-induced Ca2+ release as examined by photolysis of caged Ca2+ in single ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Ca2(+)-induced Ca2+ release as examined by photolysis of caged Ca2+ in single ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider