April 1, 1986AJP Cell Physiology

Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle

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Population

Isolated rat ventricular myocytes

Comparison

Depolarization with 50 mM KCl, with… vs Baseline conditions and control solutions

Design

Preclinical

Authors

SSS S SheuUniversity of Rochester Medical Center VSVishal SharmaNational Bureau of Animal Genetic Resources AUAdriana UglesityBrandeis University

Discussion

Member takes

Implication

NCX contributes to depolarization-induced Ca2+ rise alongside L-type channels in rat myocytes; hypothesis-generating with no current clinical implications.

Structured PICO

Population

Isolated rat ventricular myocytes

Intervention

Depolarization with 50 mM KCl, with manipulations including verapamil (5 microM), caffeine (10 mM), and replacement of extracellular Na+ with Li+ or tris(hydroxymethyl)aminomethane

Comparator

Baseline conditions and control solutions (presence of extracellular Na+)

Outcome

Cytosolic Ca2+ concentration ([Ca2+]i) measured with quin 2surrogate

Voltage-sensitive Na+-Ca2+ exchange contributes to the increase in cytosolic Ca2+ during depolarization in rat ventricular myocytes, alongside voltage-sensitive Ca2+ channels.

Cite This Study

Sheu et al. (1986) studied this question.

synapsesocial.com/papers/6a71016575498292b70a7d93 https://doi.org/10.1152/ajpcell.1986.250.4.c651

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Implication

NCX contributes to depolarization-induced Ca2+ rise alongside L-type channels in rat myocytes; hypothesis-generating with no current clinical implications.

Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider