Why the study?
Does the ETA receptor antagonist BMS-182874 suppress neointimal development in balloon-injured rat carotid arteries?
Population
Rats with balloon-injured carotid arteries and cultured rat aortic smooth muscle cells
Comparison
BMS-182874 vs Vehicle
Design
Preclinical
Follow-up
2 weeks after injury
Authors
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Does not support clinical use; hypothesis-generating for ETA antagonism in experimental restenosis.
Does the ETA receptor antagonist BMS-182874 suppress neointimal development in balloon-injured rat carotid arteries?
The ETA receptor antagonist BMS-182874 suppresses neointimal development in a rat model of balloon injury, suggesting potential utility in preventing restenosis.
Ferrer et al. (1995) studied this question.
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