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November 2, 2011PLoS ONEOpen Access

β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure

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Why the study?

Does β-AR blockade reduce ER stress and apoptosis in experimental models of cardiac hypertrophy and heart failure?

Population

Sprague-Dawley rats with cardiac hypertrophy and heart failure induced by abdominal aortic constriction or…

Design

Preclinical

Follow-up

4 or 8 weeks (banding model), 2 weeks (isoproterenol model)

Authors

LNLi NiCZChangqing ZhouQDQuanlu Duan

Discussion

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Overview

May inform β-blocker mechanisms in experimental HF; leaves open translation to human therapy.

Structured PICO

Does β-AR blockade reduce ER stress and apoptosis in experimental models of cardiac hypertrophy and heart failure?

P
Population
Sprague-Dawley rats with cardiac hypertrophy and heart failure induced by abdominal aortic constriction or isoproterenol subcutaneous injection; cultured cardiomyocytes; and failing hearts from patients with end-stage heart failure.
I
Intervention
Oral β-AR blockers
O
Outcome
Cardiac remodeling, left ventricular function, ER stress (ER chaperones expression), apoptosis, and CaMKII activationsurrogate

β-AR blockade reverses ER stress and apoptosis in experimental models of heart failure, providing a mechanistic explanation for their established therapeutic benefit.

Cite This Study

Ni et al. (2011) studied this question.

synapsesocial.com/papers/6a71025231a3df8243293f28https://doi.org/10.1371/journal.pone.0027294
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Also Consider

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  1. 1β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure2003 · 307 citations
  2. 2Sustained β <sub>1</sub> -Adrenergic Stimulation Modulates Cardiac Contractility by Ca <sup>2+</sup> /Calmodulin Kinase Signaling Pathway2004 · 189 citations
  3. 3Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of β-adrenoceptor blockade2002 · 29 citations
  4. 4Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II2003 · 380 citations
  5. 5Isoproterenol-Induced Heart Failure in the Rat is Associated with Nitric Oxide-Dependent Functional Alterations of Cardiac Function2009 · 121 citations